Chemistry

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  • IDD has worked on a wide variety of targets each requiring a customized strategy and unique blend of synthetic and medicinal chemistry.

    Specific medicinal chemistry areas of expertise include:

    • High-throughput screening (hit evaluation)
    • Lead identification and optimization based on well defined screening cascade (typically > 2000 novel compounds synthesized per program
    • Molecular modeling
    • X-ray crystallography
    • Effective patent strategy development
    • Data mining

  • Specific synthetic organic chemistry areas of expertise

    • Heterocyclic chemistry (e.g. imidazoles, benzimidazoles, quinazolinones, indoles, pyrazoles, pyrazine, pyrrolepyrimidines, pyridines, oxazole, anilinopyrimidines and triazines)
    • Transition metal catalyzed cross coupling reactions (Suzuki, Stille, Buchwald, Heck),
    • General oxidation and reduction chemistry
    • Peptide coupling reactions
    • Alkylations
    • Acylations
    • Protecting group chemistry
    • Ozone reactions
    • Hydrogenation
    • Parallel/high speed synthesis
    • Amino acid chemistry
    • Asymmetric catalysis
    • Natural product synthesis